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[ TRADE & PRODUCTS > Partners In The Making ]

echnological advancements such as microcellular phones and more efficient, hybrid automobiles have grabbed media attention, but exciting advances are continually being made by the biotechnology and chirotechnology sectors. Innovative new drugs and antibody research are in high demand, and Chem-Tech Research Incorporated (C-TRI) is responding to the call. Founded in April 1998, C-TRI initially began as a solely research-oriented venture company, but has since rapidly expanded into four major divisions: biotechnology, pharmaceuticals, fine chemicals and the company¡¯s Central Research Institute. C-TRI is pursuing numerous research projects in the chemical and biological fields with a strong focus on the value-added utilization of avian (bird) egg components as base materials for a new range of pharmaceutical products. C-TRI¡¯s biotechnology division has chalked up a number of commendable achievements in its brief history. Through its first-rate antibody research capability, C-TRI successfully developed the IgY (egg yolk immunoglobulin) immune-system building antibody. The production of an antibody such as this is a testament to CTRI¡¯s ongoing dedication to the improvement of healthcare and personal wellbeing.


  CHIRAL DRUG DEVELOPMENT
  C-TRI¡¯s success in antibody research is well timed as the entire antibody industry is on a steady ascent. Recent reports by the D&MD Antibody Market Update point to a bright future for the industry. The antibody therapeutics market is expected to grow by 30 percent annually, reaching over $7 billion by 2004. As of end-2002, the industry introduced two newly approved antibodies, bringing the total to 13. Many of these antibodies are forecasted to generate annual sales of $1 billion each.
  The fine chemistry division applies chirotechnology to produce high value-added medicines. This technology is becoming more important as a major portion of currently produced medicines is manufactured with optically active, or chiral compounds. According to Prof. Albert Chan Sun-Chi, chair professor of chemical technology at the Hong Kong Polytechnic University, ¡°The field of chirotechnology is one of the most important emerging technologies. In addition to high scientific interest, the economic potential of chirotechnology is tremendous. World market sales of chiral drugs are estimated to be more than $100 billion.¡±

  COMBATTING STOMACH ULCERS
  Applying this technology in the production of innovative new drugs, C-TRI has patented the production of Clarithromycin, the only antibiotic known to be effective against the stomach ulcer bacteria, Helicobacter pylori. Furthermore, C-TRI has also developed patents for Terbinafine, a next-generation antifungal treatment, and Lansoprazole, which is used to prevent ulcers by blocking the production of acid by the stomach.
  C-TRI has patented Clarithromycin in 45 countries, and ranks as the second largest producer in the world of this antibiotic. C-TRI has recently completed development of several products, for which it is currently in the process of patent application and pilot production. C-TRI¡¯s revenues from Clarithromycin in the United States and Japan are accelerating, and the company will begin sales in Europe by 2004. As C-TRI broadens its research and development effort into new fields of biotechnology, the potential expands for revenue generation on a considerable scale.
  C-TRI is well regarded for its superb research capability. Manufacturing products based on its own in-house developed technologies, the company is well positioned to become a leading player in the global biotech market.



  C-Tri has developed a transgenic hen. Can you explain what this is and its purpose?
  If you inject a human gene into a hen¡¯s gene, the hen will carry the human gene and so becomes ¡°transgenic.¡± We can then extract human protein from the eggs that the hen lays to mass-produce erythopoieten (EPO, a growth factor used to combat low red blood cell counts following chemotherapy), insulin, and human growth hormones.

  How big is the market for these human proteins?
  Only a small number of research organizations around the world are exploring this particular field of science. However, it¡¯s estimated that the global market for human proteins is $25 billion annually with demand focused on the United States, Europe and Japan.

  C-Tri has become one of the most successful and admired biotech companies in Korea. Do you have a personal or company philosophy that may have contributed to this success?
  Many scientists who studied abroad come back to Korea and opt to lead comfortable lives working for national research institutes, private labs and universities. Yet, it is highly likely that working for a big organization can kill your creativity and spirit of inquiry. A venture firm creates something out of nothing. Thus without investing passion and effort, you will get nowhere. In order to single-handedly launch the entire operation from planning, laying the foundation to completing the process, one should be creative and have a progressive attitude. Since technology is the lifeline of start-up companies, the CEO should create a free environment where researchers can pursue whatever field of endeavor they wish.
  In technologically advanced countries, venture firms invest 20 percent to 30 percent of their revenue into R&D. Considering Korea¡¯s technological level, venture firms should consistently invest at least 50 percent into R&D. This is the ratio we maintain today although in the early days of C-Tri, 90 percent of revenue went into R&D. I believe that without this kind of investment, Korea will never escape its status of technological dependency on other advanced nations.

  How do you organize your research effort?
  We employ what we call our ¡°Triple-Five¡± system whereby five researchers form one group and are given 500 million won ($420,000) every year to develop a new medicine within five years. C-Tri is concentrating its investment in the field of immunity in order to discover its true nature and gain the ability to control it with the help of innovative medicine.

  Does C-Tri have research affiliations with other companies or institutes?
  C-Tri has a German subsidiary through which it pursues research in taxol, one of the newer chemotherapy drugs at the University of Regensburg. Also, we maintain a genome information-sharing program with Macrogen, a leading Korean biotech company that is mapping the Korean genome structure. With the results we aim to expedite the development of new drugs.

  What kind of partnerships are you looking for at present?
  We would like to forge an alliance with a major U.S. pharmaceutical firm to help us build brand awareness and facilitate marketing of our products among American clients.

by Jennifer Kim ( jennifer.kim.a@utoronto.ca)

  For more information on another top 100 promising medium-sized South Korean companies seeking foreign investment, please contact the Investment Consulting Team of the Korea Investment Service Center (KISC).
Tel: 82-2-3460-7550/4

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